ea0031oc5.3 | Pituitary and neoplasia | SFEBES2013
Newey Paul
, Nesbit M Andrew
, Rimmer Andrew
, Head Rosie
, Gorvin Caroline
, Attar Moustafa
, Gregory Lorna
, Wass John
, Buck David
, Karavitaki Niki
, Grossman Ashley
, McVean Gilean
, Ansorge Olaf
, Thakker Rajesh
Pituitary non-functioning adenomas (NFAs), arising mostly from gonadotroph cells, represent the second most common type of pituitary tumour, after prolactinomas. NFAs are monoclonal in origin, but mutations of genes associated with hereditary pituitary syndromes (e.g. MEN1, AIP, CDKN1B, and PRKAR1A), classic oncogenes or tumour suppressor genes are rarely found. We therefore performed whole-exome sequence analysis to determine the tumourigenic events in pituitary NFAs using DN...